While exploring space for new habitable worlds, a probe belonging to the Life Foundation, a bio-engineering corporation, discovers a comet covered in symbiotic lifeforms. They bring four samples back to Earth, but one escapes and causes the ship to crash in Malaysia. The Life Foundation recovers the other three and transports them to their research facility in San Francisco, where CEO Carlton Drake learns that the symbiotes cannot survive without oxygen-breathing hosts, which often fatally reject the symbiosis. Investigative journalist Eddie Brock reads about Drake’s human trials in a classified document in the possession of his fiancée Anne Weying, an attorney involved in preparing a lawsuit defense for the Life Foundation. Brock confronts Drake, leading to both Brock and Weying losing their jobs. Consequently, Weying ends their relationship.
Six months later, Drake is getting closer to achieving successful symbiosis. Brock is approached by Dora Skirth, one of Drake’s scientists who disagrees with his methods and wants to help Brock expose him. She helps Brock break into the research facility to search for evidence, and he learns that an acquaintance of his, a homeless woman named Maria, has become one of Drake’s test subjects. Brock attempts to rescue Maria, but she attacks him and the symbiote possessing her transfers from her body to his, leaving her dead. Brock escapes, but he soon begins displaying strange symptoms and reaches out to Weying for help. Her new boyfriend, Dr. Dan Lewis, examines Brock and discovers the symbiote. Meanwhile, Drake executes Skirth for her betrayal by exposing her to the remaining captive symbiote, which ultimately dies. This leaves the symbiote inside Brock as the only known surviving specimen.
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